Innate Immunity is a highly ranked, peer-reviewed open access journal and is the official journal of the International Endotoxin & Innate Immunity Society (IEIIS).

The aim of the journal is to provide a single interdisciplinary forum for the dissemination of new information on innate immunity in humans, animals, and plants.

Thus, the journal welcomes manuscripts from researchers actively working on all aspects of innate immune responses, including humoral, cellular, and clinical topics. The journal specifically welcomes submissions focusing on the interaction of cells with endotoxin- and exotoxin-related ligands from Gram-positive and Gram-negative bacteria, viruses and plants, assessing the responses by multi-omics approaches such as, but not exclusively, RNASeq, lipidomic and metabolomic responses. It also accepts manuscripts describing new immunologically active bacterial, viral, fungal, parasitic, and plant components, their receptors, signalling pathways, and induced mediators, as long as they describe a clear link between the identified and described component and the innate immune response.

Furthermore, Innate Immunity encourages submissions that take advantage of a wide array of model systems, including but not limited to humans, rodents, insects, plants and beyond, to probe the underlying principles involved. However, Innate Immunity is not accepting data that were generated in cell lines only. It has become increasing clear that such data vary widely between the same cell line used in different labs, and that the data are often impacted by the transformation of the cells used to generate the cell line. Thus, data generated in cell lines will only be accepted as part of a manuscript that assesses their biological relevance by reproducing the data in primary test systems, such as primary cells, organ cultures or indeed in vivo systems.

The journal includes Original Research articles, Research Notes, Reviews and Mini-reviews. In addition, Innate Immunity has introduced a new article type ‘Technical Note’ which gives authors the opportunity to describe novel methods, reagents, software, codes or databases, techniques, or significant improvements to established protocols. More information can be found in the manuscript submission guidelines under Article Types.

If you have any questions relating to the appropriateness of your manuscript for submission to Innate Immunity, please contact the Editor-in-Chief, Prof Dirk Werling at dwerling@rvc.ac.uk