Human and Experimental Toxicology (HET), an international peer-reviewed journal, is dedicated to publishing nonclinical and clinical original research papers and in-depth reviews that comprehensively cover functional, biochemical, and structural disorders in toxicology. The principal aim of HET is to publish timely high impact hypothesis driven scholarly work with an international scope.

The journal publishes on:

Structural, functional, biochemical, and molecular effects of toxic agents
Studies that address mechanisms/modes of toxicity
Safety evaluation of novel chemical, biotechnologically-derived products, and nanomaterials for human health assessment including statistical and mechanism-based approaches
Novel methods or approaches to research on animal and human tissues (medical and veterinary patients) investigating the functional, biochemical, and structural disorder
In vitro techniques, particularly those supporting alternative methods
Utilization of novel approaches such as exploring adverse outcome pathways e.g. in the service of risk assessment of chemicals
Papers submitted will be judged on the basis of scientific originality and contribution to the field and quality and subject matter. Authors must clearly identify chemically the material tested and briefly explain what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is.

HET does not accept case reports and case studies. HET does not accept papers on herbal or other extracts unless sufficient chemical characterization of the material under investigation is supplied. HET does not publish routine descriptive toxicological studies which do not address also mechanistic issues of the chemical and the potential applications of the observations of the studies. HET also considers that the selection of doses of experimental studies must carry relevance to human situations, i.e. studies using excessive dose levels are not considered. Radiation biological studies do not belong to the key areas of interests of the journal and will only exceptionally considered.

Manuscripts must address at least one of the following:

Adverse effects induced by a chemically defined substance and/or the mechanism underlying the toxic phenomenon
New techniques for assessing potential toxicity, including molecular and systems biology
Toxicological examinations of specific chemicals, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability
Visionary studies exploring new innovative paradigms of toxicology and risk assessment in order to promote the development of the science of toxicology
Well designed and characterized studies with negative results
Only papers that have not been previously published, that fit in the above mentioned scope, and that have been reviewed by experts in the field before publication will be accepted. Cover letters must state that the paper is new, original, and is not under consideration for publication elsewhere. Papers pending in other journals will not be considered. Co-authors should be individuals who have contributed substantially to the content of the papers. All authors must declare any potential conflict of interest and all financial support.

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